Endocrine Abstracts

Patients with craniopharyngioma are frequently obese with a high prevalence of vascular morbidity. Many patients with treated craniopharyngioma have severe GH deficiency (GHD), which independently results in abnormal body composition and increased cardiovascular risk. This study investigated how GH treatment influences body composition in adults with treated craniopharyngioma and GHD.Using the electronic database Diabeta3® we identified 50 patients ...

Introduction: Endocrine deficiency as a result of glandular infiltration by metastatic cancer is considered rare. Metastases to the adrenal cortex are relatively common and we present the clinical presentation and radiological appearances of cases involving pituitary and adrenal metastases.Case histories: Case 1: An 84 year old male with bronchogenic carcinoma presented with lethargy, polyuria and dehydration. The serum Na+ was 156 mmol...

Objective: To determine whether transdermal oestrogen (E2) preparations alter total cortisol and cortisol binding globulin (CBG) concentration similarly to oral E2 treatment.Methods: This cross-sectional, observational study compared levels of total serum cortisol, CBG, the free cortisol index (FCI) and salivary cortisol levels (as a measure of free cortisol) in oestrogen naïve women (n=15), women taking oral oestrogen (...